At Biogen, we embrace green chemistry as an opportunity to make our drug discovery and development processes safer, more efficient and better for the environment – while also reducing costs.
Our green chemistry program helps drive process innovations that both improve product performance and also deliver environmental benefits. As part of our efforts, we use green chemistry concepts and tools, such as those developed by the ACS GCI Pharmaceutical Roundtable, to increase our chemical process efficiency, reduce our waste and optimize materials used.
For example, we’ve adopted a ‘green-by-design’ approach to drug substance manufacturing for two of our early phase pipeline projects to treat multiple sclerosis and neuropathic pain, respectively. This approach reduced waste upwards of 70 percent, based on process mass intensity (PMI) measurements. By designing for sustainability early in the development process, we are not only reducing waste and saving on resources, we are also reducing our development time and increasing the opportunity to bring critical drugs to patients sooner.
Externally, we are working to effect change throughout our industry. We are involved in the green chemistry working group of the International Consortium of Innovation & Quality in Pharmaceutical Development (IQ Consortium), with a focus on the development of green chemistry metrics. We are also actively engaged in two working groups of the ACS GCI Pharmaceutical Roundtable – one working group on influencing the research agenda and one on flow chemistry.
Read more about our Green Chemistry initiatives to support our climate strategy in our Spotlight Stories feature.